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Cloperastine fendizoate
CAS No. 85187-37-7
Cloperastine fendizoate( —— )
Catalog No. M33208 CAS No. 85187-37-7
Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | 38 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCloperastine fendizoate
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NoteResearch use only, not for human use.
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Brief DescriptionCloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).
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DescriptionCloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
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In VitroCloperastine inhibits the hERG K+ currents in a concentrationdependent manner with IC50 value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
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In VivoIn the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number85187-37-7
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Formula Weight648.19
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Molecular FormulaC40H38ClNO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (15.43 mM; Ultrasonic )
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SMILESClc1ccc(cc1)C(OCCN1CCCCC1)c1ccccc1.OC(=O)c1ccccc1C(=O)c1ccc(O)c(c1)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120(3):165-75.?
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